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Lund University Publications

The protein expression data is derived from antibody-based protein profiling using … SATB2 is a marker of osteoblastic differentiation in benign and malignant mesenchymal tumours. Although SATB2 is not specific for osteosarcoma, it has the potential to be a useful adjunct in some settings, particularly in the distinction between hyalinized collagen and osteoid. 2020-06-07 SATB2 was then identified as a potential immunohistochemical marker of human colorectal epithelium through screening of the Human Protein Atlas database by Magnusson et al. 3 The authors characterized the expression profile of SATB2 in normal human tissues using tissue microarrays, and found it to be highly expressed in the epithelium of the lower gastrointestinal tract (including appendix, colon, and … Our results indicate that SATB2 is a highly sensitive marker (100% sensitivity) for metastatic MKT-AdexGCCs with high specificity (100% specificity when showing strong staining in at least 75% cells) among MKTs. SATB2 is a useful marker for determining the primary sites of MKTs of the ovary.

Satb2 pathology outlines

SATB2 has been proven to be negative in POMNs with the exception of cases arising from teratoma, making it a superior marker in comparison to CK20 and CDX2 [15,16,17]. 2018-02-01 · Abstract. SATB2 (Special AT-rich sequence-binding protein 2) has recently been shown to be a specific biomarker of colorectal cancer (CRC). The aim of this study was to investigate the diagnostic potential of SATB2 as a means of detecting a CRC origin for liver metastases. Down‐regulated expression of SATB2 is associated with metastasis and poor prognosis in colorectal cancer. †. Shuang Wang.

We hypothesized that SATB2 IHC can reliably identify primary and metastatic signet ring cell carcinomas of lower GI tract origin. SATB2 and CDX2 IHC was performed on 159 primary (n=93) and metastatic (n=66) signet ring cell carcinomas of GI tract origin and 13 metastatic breast carcinomas with signet ring cell features. SATB2: MIM i: 119540, phenotype: OpenTargets i: ENSG00000119042: Orphanet i: 251019, 2q32q33 microdeletion syndrome 251028, SATB2-associated syndrome due to a chromosomal rearrangement 576283, SATB2-associated syndrome due to a pathogenic As the need for a more colorectal-specific marker has emerged, special AT-rich sequence-binding protein 2 (SATB2) has been used with success and promise.

2020-12-31T05:04:58Z https://lup.lub.lu.se/oai oai:lup.lub.lu

The SATB2 protein has important roles in how organs and systems in the human body develop. 2017-01-24 The designation of SATB2 ‐associated syndrome (SAS) was recently proposed by Docker et al.

DiVA - Sökresultat - Diva Portal

Additional Information. Each year, the PM5 program will feature two different markers Definition. Breast carcinoma exhibiting either a mesenchymal (or other non- epithelial) component or squamous differentiation Care of marmosets in the laboratory, pathology and outline of statistical evaluation of SATB2 is a marker of osteoblastic differentiation in benign and malignant Jan 22, 2021 Topic Outline · Local tumor extent · Regional nodes · Extramural non-nodal tumor deposits · Tumor regression after neoadjuvant therapy May 14, 2015 That's why I like to re-review pathology specimens and why I so strongly advocate for seeing a NET specialist.

SATB2 is a DNA-binding protein that specifically binds nuclear matrix attachment regions and is involved in transcriptional regulation and chromatin remodeling. SATB2 shows a restricted mode of expression and is expressed in certain cell nuclei. The SATB2 protein is … 2017-03-18 2019-06-25 2016-12-01 SATB2: GeneReviews i: SATB2: HGNC i: HGNC:21637, SATB2: HPA i: ENSG00000119042, Group enriched (brain, intestine, lymphoid tissue) MalaCards i: SATB2: MIM i: 119540, phenotype 608148, gene: neXtProt i: NX_Q9UPW6: OpenTargets i: ENSG00000119042: Orphanet i SATB2-associated syndrome (SAS) is caused by changes in the SATB2 gene. This gene is on chromosome 2 at position q33.1 and makes a protein called SATB2. The SATB2 protein works as a transcription factor for some other genes. The SATB2 protein has important roles in how organs and systems in the human body develop.
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Pathologist Job Description. Mostly working in hospitals and medical centers, pathologists use laboratory tools to run tests to check specimens for the presence of disease and also perform research work. Please note that Pathology no longer accepts single case studies involving DNA mutations. Correspondence Correspondence will be subject to Editorial Board review in the first instance and will be sent for external review if required. The title must be short and there should be … Diagnostic Pathology disseminates the latest advances in molecular, digital and virtual pathology research worldwide, with a special focus on technological Pathology is the study of the causes and effects of disease or injury.The word pathology also refers to the study of disease in general, incorporating a wide range of biology research fields and medical practices.

Not myxoid. May be present: Information about SATB2 Associated Syndrome!
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2020-12-31T05:04:58Z https://lup.lub.lu.se/oai oai:lup.lub.lu

SATB2 expression was also detected in 15% of ovarian endometrioid carcinoma but less than 5% of other ovarian histotypes. SATB2 is a 733 amino-acid homeodomain-containing human protein with a molecular weight of 82.5 kDa encoded by the SATB2 gene on 2q33. The protein contains two degenerate homeodomain regions known as CUT domains (amino acid 352–437 and 482–560) and a classical homeodomain (amino acid 614–677).

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DiVA - Sökresultat - Diva Portal

Selective nuclear expression in large intestine and subsets of neuronal cells in brain.

DiVA - Sökresultat - Diva Portal

The Our mission is to provide useful professional information to practicing pathologists and laboratory personnel, through our textbook, in 15 seconds or less. The Role of SATB2 as a Diagnostic Marker for Tumors of Colorectal Origin. American Journal of Clinical Pathology, 141(5), 630-638. ' The Role of SATB2 as a Diagnostic Marker for Tumors of Colorectal Origin ', American Journal of Clinical Pathology, vol.

Topic Completed: 1 February 2017. Definition: Special AT-rich sequence-binding protein 2 (SATB2) also known as DNA-binding protein SATB2 is a protein that in humans is encoded by the SATB2 gene. SATB2 is a DNA-binding protein that specifically binds nuclear matrix attachment regions and is involved in transcriptional regulation and chromatin remodeling. * IHC. neuroendocrine tumors SATB2 is part of the family of matrix attachment region-binding transcription factors, and has developmental roles in craniofacial, neural, and osteoblastic differentiation. Recently, SATB2 has been shown to be highly expressed in the epithelium of the lower gastrointestinal tract, with a relatively ….